I think it might be psychological and here is my reasoning.

Most people taking accutane have severe acne that inhibits them socially. They often times think if they get rid of the acne, theyll be more open with people. When the acne’s gone, and they see that only a few things have changed, they become depressed. I think that Accutane as a depressant is more psychological than drug-related. Would I be right in saying this?